![]() Hematopoietic stem cell transplantation has been the standard therapy for several oncological and hematological disorders since the early 70’s ( 8). In this context, hematopoietic stem cell transplantation (HSCT) has emerged as an alternative therapy for severe and refractory ADs. There is a group of patients with refractory and life-threatening states for whom the results of conventional therapy have been considered unsatisfactory. The majority of patients achieve short-term disease control with immunosuppressive therapy including biological therapies, but long-term remission or a definitive cure remains unattainable ( 7). ![]() However, a trigger like an environmental exposure is needed to initiate frank autoreactivity in a genetically predisposed individual ( 2, 6). Epidemiologic studies have shown that genetic factors are major determinants of susceptibility to ADs ( 4, 5). The knowledge of the etiology of ADs remains limited. In some conditions, 85% or more of the patients are female ( 3). ADs disproportionally occur more in women. The concept of “autoimmune disease” includes a wide spectrum of pathologies that vary in biological and clinical features.Īutoimmune diseases (ADs) are among the most prevalent diseases in the United States, affecting approximately 7% of the population ( 2). Autoimmune disease is defined as a clinical syndrome caused by the activation of T cells and/or B cells in the absence of an ongoing infection or other discernible cause ( 1). It was unbelievably frustrating because the three things that doctors are constantly telling you to do after transplant is to move around, go for walks, and eat and drink, drink, drink water, water, water, water, water, like they are measuring how much water and food intake and exercise I’m doing every single day.Autoimmunity is an inappropriate response of the immune system directed against self-tissues. It resolved itself.Īfter about a week, it got slowly better. So I couldn’t speak and I had a very difficult time swallowing. They did give me one type of chemo that is very much I don’t remember the name, but it’s very much known for creating mouth sores and I had mouth sores all the way down inside my throat. I did have mouth sores, which with high dose chemo and many other types of chemo is common. Lots of upset stomach, I did not want to eat. The steroids also made me feel a little bit weird. The side effects were very similar to the chemo and more than anything else, that was the chemo that I was feeling side effects for more than the transplant. Here’s what some cancer patients have to share about their personal experiences and what to expect after stem cell transplant: Patients often report a strong smell of creamed corn or garlic in the room or in their mouth. ![]() If an oncologist or other healthcare provider has recommended, SCT for you or a loved one, you may wonder about what to expect after stem cell transplant. Miklos What to expect after stem cell transplant Maybe it’s a brother or sister or HLA-identical donor whose blood destroys the white cells, red cells, and regrows and reconstitutes the normal blood system. Some of your patients may have had an allogeneic transplant which is truly the immune therapy of someone else’s immune system. We’ve tried high-dose chemotherapy and I’m a stem cell transplanter, so the notion of using high-dose chemotherapy with stem cell rescue or what your patients will know as an auto transplant, has provided much benefit to the patients of mantle cell.
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